Changes in markers of cobalamin status after cessation of oral B-vitamin supplements in elderly people with mild cobalamin deficiency.
Eussen SJ, Ueland PM, Hiddink GJ, Schneede J, Blom HJ, Hoefnagels WH, van Staveren WA, de Groot LC.
1Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Mildly cobalamin-deficient elderly were supplemented with 1000 mug cobalamin (group C, n=34), 1000 mug cobalamin with 400 mug folic acid (group CF, n=31) or a placebo (n=30) for 6 months. Participants provided one single blood sample 3, 5 or 7 months after cessation of supplementation to monitor early changes in plasma concentrations of cobalamin, holotranscobalamin (holoTC) and methylmalonic acid (MMA). At the end of supplementation (groups C+CF), one participant met our criteria for mild cobalamin deficiency, as did 13, 14 and 43% of the participants assessed at respectively 3, 5 and 7 months post-supplementation. Cobalamin and holoTC declined on average with 47 and 56% relative to concentrations at the end of supplementation for the group assessed at 7 months post-supplementation. Essentially similar declines were observed for those participants assessed at 3 and 5 months post-supplementation. Mean MMA concentrations increased by 15% (P=0.07) in those participants assessed at 3 and 5 months post-supplementation, and increased by 50% (P=0.002) in those participants assessed at 7 months post-supplementation. Considering MMA as a sensitive tissue marker for cobalamin status, oral supplementation may afford adequate cobalamin status for a period of up to 5 months after cessation in the majority of participants.European Journal of Clinical Nutrition advance online publication, 4 July 2007; doi:10.1038/sj.ejcn.1602834.
PMID: 17609694 [PubMed - as supplied by publisher]
« Back to abstracts
|
News
Coming Soon ! The full video recording of the Euromedlab 2007 Active B12 workshop will be available in the next few weeks, register for your copy.
Live CME Web Conference on vitamin B12 deficiency, Prof. Ralph Green, Dec 13th 2007, register now.
read more »
Meetings
8-11 December, 2007
American Society of Hematology, Atlanta, booth 544
read more »
|
