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Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum.
Aarhus Sygehus, Denmark. almor@as.aaa.dk
Dept. of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Denmark. almor@as.aaa.dk

We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy.

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