Monthly Archives: June 2011

Pernicious Anaemia Society, June 2011

Pernicious Anaemia Society: Diagnosing B12 Deficiency – Problems, Consequences and Resolution
June 2011, Porthcawl, Wales

The Pernicious Anaemia Society held a symposium and study day in Porthcawl, Wales in June 2011 to highlight the problems of diagnosing B12 deficiency and the potentially serious implications. A number of informative talks were given from leading experts on Vitamin B12.

The speakers recognised that current testing for B12 status using the Total B12 assay is flawed due to the non-specific nature of the test. Several of the speakers recommended the use of the more specific and sensitive Active-B12 assay for diagnosing B12 deficiency.

Dr Fiona Porter-Smith, GP, Cwm Garw Practice, Bridgend.
The Problems of Diagnosing B12 Deficiency: The Patient Perspective

Professor John Scott, Professor of Molecular Medicine, Trinity College Dublin
The Absorption of Vitamin B12 and it’s Interruptions; revisited

Dr Anne Molloy, Clinical Lead, Vitamin Research Group, Trinity College Dublin
Should HoloTC be the first line diagnostics procedure for assessment of vitamin B12 status? A comparison of the performance of blood indicators of tissue B12 status

Professor Helga Refsum and Professor David Smith, University of Oxford
Low-normal B12 status: assessment, prevalence and association with disease

Dr Siddarth Banka, Regional Genetics Service, University of Manchester
Pernicious Anaemia – Genetic Insights

Professor John Hunter, Professor of Medicine, University of Cranfield
Does the large bowel sometimes have an effect on B12 metabolism?

Dr Joseph Chandy, GP, Shinwell Medical Centre
A Protocol for B12 Diagnosis and Treatment by Primary Care Clinicians

The symposium concluded with a powerful documentary made by the society entitled ‘Living with the Fog’. The film highlights the serious issues in diagnosis and treatment of B12 deficiency and the devastating effects it can have on patients.

For further information please see

8th International Conference on Homocysteine Metabolism Lisbon, June 19-22nd 2011

8th International Conference on Homocysteine Metabolism
Lisbon, Portugal June 19-22nd 2011

Several sessions at the conference focussed on Homocysteine in relation to Vitamin B12. The importance of correctly estimating B12 levels was once again highlighted. Some of the presentations and posters from the conference are shown below. For more information on these presentations, please contact Axis-Shield.

Plasma vitamin B12 and holoTC – between uptake and utilisation
Ebba Nexo (Aarhus, Denmark)
Vitamin B12 intracellular trafficking
Brian Fowler (Basel, Switzerland)
Holotranscobalamin predicts tissue vitamin B12 status (red cell cobalamin) in elderly subjects with significantly greater accuracy than either total serum cobalamin or methylmalonic acid
Anne Molloy (Dublin, Ireland)
Baseline homocysteine is crucially important in trials with B vitamin: the VITACOG trial
David Smith (Oxford, United Kingdom)
Cognitive function in an elderly population: interaction between vitamin B12 status, depression and apolipoprotein E4. the Hordaland homocysteine study
Anna Vogiatzoglou (Reading, United Kingdom)